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Enclomiphene Benefits and Usage: A Comprehensive Guide

Enclomiphene Benefits and Usage: A Comprehensive Guide
Dr. Constance Odom, MD Picture of Dr. Constance Odom, MD

Medically reviewed by

Written by our editorial team.

Last Edited 4 min read

Enclomiphene has many benefits for those who take it and it can be used for a variety of reasons:  Firstly, it is commonly prescribed for those who are suffering from secondary hypogonadism.  It is also effective in increasing low testosterone levels caused by conditions such as obesity, metabolic syndrome, and type 2 diabetes.

If you are taking enclomiphene, it’s valuable to know how this drug works and impacts your body. According to experts, it takes enclomiphene roughly two weeks for it to build up in your system and for you to begin seeing positive results. Overall, enclomiphene is very safe. However, there are some things you should do to get the maximum benefit of this medication.

What Is Enclomiphene Used For and How Does it Work?

Enclomiphene is a non-steroidal estrogen receptor antagonist that promotes gonadotropin-dependent testosterone secretion by the testes. It works by antagonizing the effects of estrogen, which can increase testosterone levels in men with secondary hypogonadism. This is achieved by restoring physiological endogenous testosterone secretion while maintaining testicular volume and potentially spermatogenesis.

Enclomiphene Dosage:

Enclomiphene has some side effects, so it is a good idea to be aware of them. Men who take enclomiphene may experience increased libido, acne, and potentially a temper. A temper typically only shows up if your enclomiphene levels are too high. 

Because of this, you should be on the lookout for these symptoms. You should always take enclomiphene as directed. Patients are usually prescribed either 12.5 milligrams or 25 milligrams of this medication. 

Which medication should you avoid when taking enclomiphene?

As with any drug, enclomiphene has interactions with some drugs. It’s important to be aware of these if you take this medication.

Be sure to avoid medications, such as abrocitinib, ospemifene, bexarotene, and fluoroestradiol F 18., according to Enclomiphene also interacts with alcohol, so you should eliminate alcohol from your diet or at least limit its consumption.

Enclomiphene and alcohol

Consuming alcohol while on Enclomiphene can cause dizzy spells and fainting. Alcohol also impacts fertility, so it is a good idea to keep an eye out for symptoms that may indicate a reaction to alcohol.

What is the best time to take Enclomiphene?

Medical experts recommend that you take enclomiphene between 7:00 a.m. and 10:00 each day, so it is a good idea to take enclomiphene within this period. Some experts recommend that you take enclomiphene twice per day.

Testosterone levels typically peak between 7:00 and 10:00 in the morning, so it is important to take your medication within this time.

Prescribed off-label for more than 30 years, enclomiphene has many benefits. Your doctor can write you a prescription. In some cases, an online doctor can prescribe this medication during an online consultation. It is a good idea to follow your doctor’s directions to get the maximum benefit of enclomiphene. Explore our article 'When is the best time to take Enclomiphene?' to learn about the pros and cons of evening and morning dosing.

What you should avoid while taking enclomiphene?

Understanding what to avoid while taking enclomiphene is crucial for ensuring its efficacy and well-being. According to PubMed, enclomiphene citrate triggers the body to produce testosterone and boosts sperm counts.

Foods to Avoid:

According to experts, treatments with Enclomiphene are most effective when combined with a healthy lifestyle, including regular exercise and good dietary habits. Therefore, junk food, processed foods, and canned or plastic-packaged foods are not recommended.

Knowing this can help you maximize the benefits of the medication and minimize potential risks.

Lifestyle Considerations

Avoid smoking as it can exacerbate potential problems. The FDA warns about the risk of blood clots in individuals taking testosterone products, underscoring the importance of avoiding smoking.

Breastfeeding Considerations

It is advisable to avoid enclomiphene while breastfeeding. Although there is no definitive evidence that enclomiphene passes through breastmilk, it is important to weigh the risks and benefits with your doctor.

Allergies and Medication Interactions

You should avoid enclomiphene if you have an allergic reaction to it. You should speak with your doctor if you have other kinds of allergies that may interfere with you taking enclomiphene. Avoid taking certain medications around the time you take your enclomiphene. This can cause interactions. 

Pre-existing Medical Conditions

If you have specific medical conditions, such as diabetes, it may be wise to avoid enclomiphene

Potential Side Effects

Enclomiphene has several side effects, including hot flashes, abdominal pain, and nausea. If you prefer to avoid these, reconsider taking this medication. Note that testosterone levels are suppressed when taking enclomiphene.

Enclomiphene use has been linked to eye problems. Because of this, it may be wise to avoid enclomiphene if you are concerned about developing eye conditions or visual spots.

One study found that enclomiphene has the potential to cause visual problems and retinal disorders. According to experts, there is much debate about Enclomiphene’s effect on blindness.

One study found that after taking enclomiphene for six weeks, concentrations of testosterone were 604 ng/dL on average at day 42 of the study. Enclomiphene is also known to cause breast tenderness and mood swings. If you don’t want to deal with these side effects, you may want to reconsider taking enclomiphene.

Is there an alternative to Encliomiphene?

If you find that enclomiphene is not the best fit for you, there are many alternative medications on the market. According to experts, Metformin is a viable alternative to enclomiphene. 

If you are trying to decide whether or not enclomiphene is the right fit for you, consider any preexisting conditions you have and other medications you are taking.

Unfortunately, though, some people get some really bad results from enclomiphene. Some men continue to suffer from symptoms of low testosterone, while others gain weight as a result of taking this medication.

Again, it’s important to weigh the pros and cons of taking this medication. You may want to avoid this medication if you don’t want to risk undesirable side effects. Not everyone has the same reaction to enclomiphene. However, it has been found to cause weight loss in certain individuals.

Key Recommendations

Enclomiphene can appear on routine urine tests, so it’s best to avoid this medication if you're concerned about test results. It can also affect your breathing, causing difficulty for some users. If you experience breathing problems, immediate oxygen administration is crucial.

Take care to avoid contact with your eyes. If enclomiphene enters your eyes, it can lead to long-term visual issues, such as palinopsia. Therefore, minimizing eye contact with this substance is essential to prevent potential visual complications.

Research indicates that enclomiphene remains active in your system even after discontinuation for four to seven years. Experts note that both transdermal testosterone and enclomiphene impact insulin, and while testosterone levels rise with enclomiphene, the increase varies among individuals.

Studies have shown that testosterone levels fluctuate depending on the time of day with enclomiphene use. However, enclomiphene does not significantly alter luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. It has been found to lower IGF-1 in men, potentially reducing cancer risk.

The best course of action is to discuss enclomiphene and its risks with your doctor. They can provide personalized advice to help you decide if enclomiphene is right for you.

20 Sources

Nu Image Medical has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.


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This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your physician about the risks and benefits of any treatment. Nu Image Medical may not offer the medications or services mentioned in this article.