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Low Dose Trazodone
Insomnia aide
Can't rest?
Supports a good night's sleep
Originally approved as an antidepressant medication, studies have found that trazodone in low doses can help increase the availability of serotonin, a chemical in the brain, which may help you feel relaxed and promotes sleep.
Prescribed
via Digital Doctor
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If Medically Appropriate
How low dose trazodone works
Low dose trazodone may exert a sedative effect to aid in sleep through antagonism of the 5-HT-2A receptor, H1 receptor, and alpha-1-adrenergic receptor. Trazodone, an antidepressant, works by inhibiting both serotonin transporter and serotonin type-2 receptors. Given the unique properties of trazodone, in low doses, it may promote relaxation and sleep with minimal side effects for most people.
Benefits
- Trazodone may be less expensive than some newer insomnia medicines because it is available generically.
- In low doses trazadone is generally not felt to be addictive.
- Trazodone is a non-controlled substance unlike some other sleep aids such as benzodiazepines.
- Studies have shown that trazodone may be useful as a sleep aid at low doses of 25-50 mg.
Dosing
Trazodone is used at doses in the range of 25 to 100 mg/day for insomnia. However, studies show that lower dosages of trazodone are effective and may cause less daytime sleepiness and fewer side effects.
Possible Side Effects
Trazodone use can lead to some common side effects such as feeling faint, vomiting, headache, dry mouth, dizziness, drowsiness, somnolence, and fatigue. In addition, especially in higher doses, trazodone has been associated with the possibility of suicidal thoughts in young adults. Contact your physician immediately if you experience suicidal thoughts, mania, irregular heart rate, prolonged erections, or hallucinations.
Contradictions
Trazodone therapy requires careful consideration for patients treated with
any class of monoamine oxidase inhibitors (MAOIs), including linezolid or IV
methylene blue. MAO inhibitors impair the metabolism of serotonin, and
concurrent administration increases serum levels of serotonin. One must have
14 days of the MAOI-free period to reduce the risk of serotonin syndrome
before initiating treatment with trazodone. Concomitant use of other
serotonergic drugs, such as triptans, TCA, or fentanyl, will also increase
the level of serotonin. Trazodone use requires caution in patients with
compromised liver function and renal function.
Talk to your physician for additional information or concerns.
