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For the treatment of Insomnia
Originally approved as an antidepressant medication, studies have found that trazodone in low doses can help increase the availability of serotonin. Serotonin is used by our bodies to stabilize our mood, feelings of well-being and promotes sleep. Goodbye to sleepless nights, hello good mood!
Prescribed
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If Medically Appropriate
Trazodone works by increasing the levels of serotonin within your brain. By raising the levels of serotonin in the brain, trazodone’s job is to increase the levels of this neurotransmitter and help you feel relaxed.
Within your system, trazodone behaves like a shield blocking the reuptake of serotonin by the alpha1 adrenergic receptors and H1 histamine receptors. Considering its unique properties, in low doses trazodone can help promote well-being and better sleep with minimal side effects for most people... thats a big win, thanks science!
For patients taking Trazodone, sedative effects may include a relaxed, sleepy feeling. Although trazodone was originally designed to treat certain forms of depression, studies have shown that it may be useful as a nighttime sleep aid when taken at low doses for patients struggling with insomnia.
Dosing
Trazodone is used at doses in the range of 25 to 100 mg/day for insomnia. However, studies show that lower dosages of trazodone are effective and may cause less daytime sleepiness and fewer side effects.
Possible Side Effects
Trazodone use can lead to some common side effects such as feeling faint, vomiting, headache, dry mouth, dizziness, drowsiness, somnolence, and fatigue. In addition, especially in higher doses, trazodone has been associated with the possibility of suicidal thoughts in young adults. Contact your physician immediately if you experience suicidal thoughts, mania, irregular heart rate, prolonged erections, or hallucinations.
Contradictions
Trazodone therapy requires careful consideration for patients treated with
any class of monoamine oxidase inhibitors (MAOIs), including linezolid or IV
methylene blue. MAO inhibitors impair the metabolism of serotonin, and
concurrent administration increases serum levels of serotonin. One must have
14 days of the MAOI-free period to reduce the risk of serotonin syndrome
before initiating treatment with trazodone. Concomitant use of other
serotonergic drugs, such as triptans, TCA, or fentanyl, will also increase
the level of serotonin. Trazodone use requires caution in patients with
compromised liver function and renal function.
Talk to your physician for additional information or concerns.