What is the best GLP-1 for weight loss? A comparative look

Dr. Constance Odom, MD

Medically reviewed by

Dr. Constance Odom, MD

Dr. Constance Odom, MD

About

Constance Tambakis Odom, MD graduated in 1987 with her Doctorate of Medicine from the New York Medical College, and was an Anesthesiologist Resident from 1988 to 1991 at the Brookdale Medical Center PGY II (CA-I)-PGY IV (CA-III). She is Board Certified by the American Board of Anesthesiology since 1998 and American Academy of Anti-Aging Medicine since 2002. Constance Odom, MD is affiliated with the American Medical Association, American Academy of Anti-Aging Medicine, American Society of Anesthesiology, Georgia Society of Anesthesiology, Hellenic Medical Society of New York, North Carolina Society of Anesthesiology, and Society of Ambulatory Anesthesia.

Credentials

Medical Director At:

• Nu Image Medical
• MetroMedispa P.A.

Staff Anesthesiologist at:

• Betsy Johnson Regional Hospital in Dunn, NC
• Onslow Memorial Hospital in Jacksonville, NC
• Duplin General Hospital in Kenansville, NC

Director of Anesthesia Services at:

• Jacksonville Surgery Center in Jacksonville, NC

Written by our editorial team.

Last Edited 3 weeks ago · 6 min read

Which GLP-1 is best for weight loss? a comparative look

When considering GLP-1 agonists for weight loss, it is natural to wonder which medication might be the most effective. However, determining the "best" option can be complex. The answer may vary depending on individual needs, the specific medication, and how it is evaluated it by clinical efficacy, user experiences, or potential side effects.

What studies suggest about GLP-1 effectiveness

Clinical trials have consistently highlighted semaglutide as a front-runner among GLP-1 agonists for weight loss. Studies suggest that semaglutide might lead to greater weight loss compared to other GLP-1 agonists. For instance, research indicates that patients using semaglutide could lose a more significant percentage of their body weight than those using alternatives like liraglutide or dulaglutide.

However, it is important to note that while Semaglutide may demonstrate superior weight loss results in clinical settings, this doesn't necessarily mean it will be the best option for everyone. Factors such as side effects, adherence to the medication regimen, and individual patient responses might influence the overall effectiveness.

Comparing the potential of different GLP-1 agonists 

Semaglutide:

Semaglutide is often highlighted for its substantial weight loss potential, which could make it the preferred choice for many. Patients might experience weight loss of over 5% of their body weight, and some studies suggest this percentage could be even higher under certain conditions. However, users may need to consider the likelihood of gastrointestinal side effects, which are commonly reported.

Liraglutide:

Liraglutide also shows promise as a weight loss aid. It may offer similar benefits to semaglutide, especially at higher doses used specifically for weight management. However, because liraglutide typically requires daily injections, some patients might find it less convenient, which could affect long-term adherence.

Dulaglutide:

Dulaglutide could be a viable option for those looking for a more convenient regimen, as it is administered once weekly. While its weight loss potential might not match that of semaglutide, dulaglutide could be favored for its ease of use and better adherence rates.

Exenatide: Exenatide offers another alternative, though it might not be as effective in terms of weight loss compared to semaglutide or liraglutide. Patients may prefer exenatide for its dual daily and weekly formulations, but the trade-off might include a higher incidence of injection site reactions.

Real-world considerations

Real-world experiences suggest that the "best" GLP-1 agonist may depend on individual circumstances and preferences. While semaglutide appears to be the most potent in clinical studies, some patients might prioritize convenience or have a better tolerance for another medication. Additionally, cost and availability could play significant roles in determining the best option for weight loss.

For example, a recent news story highlighted the growing demand for semaglutide, which has led to concerns about counterfeit versions flooding the market. This issue underscores the importance of sourcing medications from reputable providers and considering all aspectsâefficacy, safety, cost, and access when choosing a GLP-1 agonist.

Choosing the "best" GLP-1 agonist for weight loss isn't straightforward and likely depends on various factors, including effectiveness, side effects, and personal preference. While semaglutide may stand out in terms of weight loss potential, other options like liraglutide, dulaglutide, or exenatide might be better suited for certain individuals. Consulting with a healthcare provider and considering all these aspects could help in making an informed decision.

References

• https://www.vanityfair.com/news/story/counterfeit-ozempic-global-growth-industry

• https://www.ncbi.nlm.nih.gov/books/NBK572151/

• https://www.jwatch.org/na57086/2024/02/13/which-glp-1-agonist-most-effective-glycemic-control-and

• https://www.healthline.com/health/type-2-diabetes/considering-glp1s

• https://www.medcentral.com/meds/which-glp-1-agonist-if-any-is-right-for-my-patient

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your physician about the risks and benefits of any treatment. Nu Image Medical may not offer the medications or services mentioned in this article.