Weight Loss Medications: what to know about GLP-1 for Weight loss

Updated on: 2024-08-22

Weight loss medications: what to know about GLP-1 receptor agonists

Prescription weight loss medications have gained significant popularity due to their effectiveness in helping individuals with obesity and weight-related health conditions manage their weight. Thanks to their rapid growth in the market, GLP-1 receptor agonists, have become some of the most sought-after medications for weight loss.

With this rising popularity, GLP-1 receptor agonists have become some of the most sought-after options for weight loss. These days, it is common to hear about GLP-1 medications through ads, articles, or word-of-mouth. Some of the most well-known options include Semaglutide, Liraglutide, Dulaglutide, and Tirzepatide.

From 2019 to 2022, the use of Semaglutide and Tirzepatide (sold as Mounjaro) saw a massive increase. In 2022 alone, over 5 million prescriptions were written for weight management, a huge jump from just over 230,000 in 2019âa staggering 2,082% increase.

Source: https://www.komodohealth.com/perspectives/prescriptions-for-trendy-diabetes-and-weight-loss-drugs-increased-over-2000-since-2019

Additionally, recent studies have shown that these medications have the potential to support weight loss. With research confirming their efficacy and safety, you might be interested in learning more about how GLP-1 medications work for weight loss and even consider trying them out.

In a recent Numerator survey of over 100,000 U.S. respondents, 11.8% reported having at least one GLP-1 user in their household, with an additional 6.4% indicating they were previous users. Most GLP-1 users (63%) use the medication for diabetes management, while 47% use it for weight loss, and 14% for both purposes. Among those focused on weight loss, 74% aim to lose 15 or more pounds.

According to Numerator, custom breakouts are:

What does GLP-1 mean?

GLP-1 stands for Glucagon-Like Peptide-1, a hormone that plays a crucial role in managing blood sugar levels. Originally, medications containing GLP-1 were developed to help individuals with type 2 diabetes by enhancing insulin secretion and slowing down glucose absorption in the gut. However, recent research has shown that these medications can also aid in weight loss.

GLP-1 Medications

GLP-1 medications are classified as GLP-1 receptor agonists. While their primary purpose is to manage blood sugar levels in type 2 diabetes, they have also gained attention for their potential to support weight loss.

These medications mimic the natural GLP-1 hormone, which helps regulate blood sugar levels. By doing so, they may reduce appetite and contribute to weight management.

The journey of GLP-1 medications began in the early 2000s, with the FDâs approval of Exenatide for diabetes treatment. Since then, several other GLP-1 receptor agonists have been developed, and their usage has expanded beyond diabetes management to potentially include weight management, whether or not the individual has diabetes. This scientific backing has increased trust and reliance on these medications for weight loss.

How do GLP-1 medications work for weight loss?

GLP-1 medications are being studied for their potential effectiveness in weight management due to their mechanism of action.

These medications work by slowing gastric emptying, which helps individuals feel full longer after eating, and by reducing hunger signals in the brain, leading to a decrease in calorie intake.

GLP-1 treatments interact with GLP-1 receptors in the body, triggering weight loss and improving metabolic function. Specifically, these medications stimulate the pancreas to produce insulin after meals, helping to lower blood sugar levels. They also bind to receptors in the brain that suppress appetite, which aids in reducing calorie consumption.

The body's natural production of the GLP-1 hormone is short-lived in the gastrointestinal tract, limiting its effectiveness in naturally promoting weight loss. GLP-1 medications extend the hormone's activity, making them more effective in managing obesity.

How GLP-1 benefits can transform your health and well-being

These medications help accelerate fat loss through the following mechanisms:

• Slowed gastric emptying: This process helps users feel full with smaller amounts of food, reducing overall calorie intake and promoting weight loss.

• Appetite suppression: GLP-1 medications influence the brain to perceive that the stomach is full, thereby reducing the desire to eat.

• Glucose regulation: By reducing glucagon secretion and increasing insulin release after meals, GLP-1 medications help stabilize blood sugar levels, reducing cravings for sugary or high-carbohydrate foods.

The transition of GLP-1 medications from diabetes treatment to a potential weight loss aid is supported by extensive research:

Clinical studies have explored the effects of GLP-1 medications on weight management. For example, research published in the New England Journal of Medicine examined the impact of Semaglutide on weight, reporting that participants experienced a notable reduction in body weight over 68 weeks.

In those with overweight or obesity, 2.4 mg of semaglutide once weekly, combined with lifestyle interventions, was associated with sustained, clinically relevant weight loss.

Additional studies, such as those reviewed in Cureus, have explored the use of GLP-1 receptor agonists in various populations, including women with polycystic ovary syndrome (PCOS). The review found that GLP-1 receptor agonists, particularly liraglutide and exenatide, are effective in promoting weight loss and improving metabolic and reproductive health in women with PCOS.

These medications led to significant reductions in body weight, body mass index (BMI), and waist circumference, along with improvements in glucose homeostasis, menstrual regularity, and pregnancy rates. However, the review also noted that while the short-term benefits are promising, further research is needed to fully understand the long-term safety and efficacy of these treatments in the PCOS population.

A systematic review published in Pharmacia discussed the potential for GLP-1 receptor agonists to improve both glycated hemoglobin levels and support weight management in individuals with type 2 diabetes. This review highlights how the GLP-1 receptor agonists may function by delaying gastric emptying and enhancing satiety.

Types of GLP-1 medications

GLP-1 medications vary in their duration of action and method of administration. Currently, there are seven GLP-1 receptor agonists approved for managing type 2 diabetes, with some also approved for weight management:

Below is a list of these medications: 

1. Wegovy: Contains the active ingredient semaglutide and is administered via a subcutaneous injection once weekly.

2. Mounjaro: Uses tirzepatide as its active ingredient, also given as a subcutaneous injection once weekly.

3. Ozempic: Another medication with semaglutide as the active ingredient, administered through a subcutaneous injection once weekly.

4. Trulicity: Contains dulaglutide and is delivered via a subcutaneous injection once weekly.

5. Saxenda: This medication includes liraglutide and is administered through a subcutaneous injection once weekly.

6. Victoza: Also containing liraglutide, it is administered by subcutaneous injection once weekly.

7. Rybelsus: A unique option that contains semaglutide, but is taken orally once daily.

If you are interested in the complete list of GLP-1 Agonists, don't hesitate to check this content: GLP-1 agonist list | How each one works

Is there a possibility of experiencing any side effects and risks with GLP-1 Medications?

While GLP-1 medications are under consideration for weight management, they are associated with certain side effects. Common side effects include nausea, vomiting, diarrhea, and constipation. These symptoms are often mild and may subside as the body adjusts to the medication.

However, it is important to note that some serious risks have been reported, such as pancreatitis, gallbladder issues, and a potential increased risk of thyroid tumors, although these are considered uncommon.

An investigation in the Journal of Clinical Medicine discussed the broader metabolic effects of GLP-1 receptor agonists, including potential cardiovascular benefits. However, the study also emphasized the importance of monitoring for gastrointestinal discomfort a common side effect of GLP-1 Medication, which can vary depending on the specific GLP-1 medication being used.

Like any treatment, GLP-1 medications are associated with potential side effects. The most common include:

• Gastrointestinal symptoms: Nausea, vomiting, diarrhea, constipation, and abdominal pain are the most frequently reported side effects. These symptoms typically diminish as the body adjusts to the medication.

• Neurological symptoms: Some users have reported headaches, dizziness, and fatigue. These are usually mild and transient.

• Other symptoms: Additional side effects may include dyspepsia, eructation, and abdominal distension.

Despite these risks, GLP-1 medications remain a competitive option when compared to other weight loss treatments.

GLP-1 Medications vs. other weight loss treatments

When considering GLP-1-for-weight-loss, it may be useful to compare these medications with other available treatments. Unlike traditional weight management medications that primarily focus on appetite suppression or metabolism enhancement, GLP-1 medications may work by influencing how the body processes food and regulates hunger. This mechanism might support more sustainable weight management over time.

In comparison to other treatments, such as SGLT2 inhibitors or phentermine, studies have explored the extent of weight reduction associated with GLP-1 medications. For instance, research cited in The Lancet Diabetes & Endocrinology noted that GLP-1 receptor agonists like Semaglutide were associated with more significant weight reduction compared to some other antidiabetic agents.

Efficacy and Safety of GLP-1 Medications for Weight Loss

When considering weight loss treatments, efficacy and safety are paramount concerns. Clinical trials have extensively evaluated the effectiveness and safety profile of GLP-1 medications in promoting weight loss.

For example, a review published in Pharmacia reported that GLP-1 receptor agonists demonstrated significant weight loss, with average reductions ranging from 0.4 kg to 5.1 kg over six months with standard weekly doses. These findings were supported by additional research published in the New England Journal of Medicine, which highlighted a 15% reduction in body weight over 68 weeks in patients using Semaglutide, a GLP-1 medication.

The study about the efficacy and safety of GLP-1 receptor agonists in the treatment of patients with type 2 diabetes demonstrates that GLP-1 receptor agonists have a serious superiority over other antidiabetic medicinal products in terms of reducing HbA1c levels and weight reduction without the risk of hypoglycemic episodes. The safety profiles of all representatives of this class are similar.

Tirzepatide demonstrates the highest efficacy in reducing both HbA1c levels by -2.37% and -1.70% with subcutaneous Semaglutide 1 mg, respectively, and body weight by -10.62 kg after administration of Tirzepatide 15 mg and by -4.86 kg with subcutaneous Semaglutide 1 mg, respectively. In clinical trials, GLP-1 agonists demonstrate cardiovascular benefits in patients with type 2 diabetes and an established risk of atherosclerotic cardiovascular disease. There is strong evidence to support the use of GLP-1 agonists in overweight or obese patients who have cardiovascular disease, impaired renal function, or are at high risk of hypoglycemia

Cost and accessibility of GLP-1 medications

The cost of GLP-1 medications can vary significantly, with prices generally ranging from $500 to $1,000 per month without insurance coverage. However, telehealth services have increasingly provided alternative options that may be more cost-effective. Online programs offering GLP-1 medications often include additional support services, such as personalized diet plans and regular consultations with healthcare professionals, which might enhance the overall treatment experience.

A review in JAMA Health Forum discussed the challenges related to the high cost of GLP-1 medications, particularly for individuals without insurance coverage. The review also pointed out how telehealth services are expanding access to these medications, potentially offering a more affordable route for those seeking weight management solutions.

To know the prices of GLP-1 Medications by prescription with Nu Image Medical, you can check here: NU Image Medical - Weight Loss Medications-

Contraindications and drug interactions

Contraindications and drug interactions with GLP-1 medications are relatively uncommon but important to consider. Due to their potency, GLP-1 medications should not be combined with other treatments for type 2 diabetes, such as metformin or insulin, as this can increase the risk of hypoglycemia.

GLP-1 medications are also contraindicated in certain populations, including:

• Pregnant women: The safety of GLP-1 medications during pregnancy has not been established.

• Patients with pancreatitis: A history of pancreatitis is a contraindication due to the potential risk of recurrent episodes.

• Patients with a history of medullary thyroid cancer: GLP-1 medications may increase the risk of thyroid tumors in these patients.

• Patients with multiple endocrine neoplasia type 2 (MEN2): Similarly, GLP-1 medications may pose a risk in patients with MEN2.

GLP-1 medications are emerging as a promising option for those seeking assistance with weight management. Understanding how these medications work, their potential benefits and risks, and how they compare to other treatments is essential for making informed decisions. When combined with lifestyle changes such as a balanced diet and regular exercise, GLP-1 medications can contribute to long-term weight management.

However, it is crucial to discuss all medications and health conditions with a healthcare provider before starting GLP-1 treatment. While these medications are generally safe and effective, they must be used correctly to maximize benefits and minimize risks. Consulting with a healthcare provider will help determine if GLP-1 for weight loss is the right approach for your circumstances.

Want to take the next step and achieve your ideal weight? Start seeing results with GLP-1 medications for weight loss.

With Nu Image Medical, you can easily find out if GLP-1 is right for you through a quick online visit. If prescribed, your medication will be delivered straight to your door, making it convenient and hassle-free.

Ready to begin your weight loss journey? Explore Nu Image Medical today and take the first step towards achieving your goals.

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your physician about the risks and benefits of any treatment. Nu Image Medical may not offer the medications or services mentioned in this article.