3 Common Side Effects of Trazodone—How to Handle Them

Dr. Constance Odom, MD

Medically reviewed by

Dr. Constance Odom, MD

Dr. Constance Odom, MD

About

Constance Tambakis Odom, MD graduated in 1987 with her Doctorate of Medicine from the New York Medical College, and was an Anesthesiologist Resident from 1988 to 1991 at the Brookdale Medical Center PGY II (CA-I)-PGY IV (CA-III). She is Board Certified by the American Board of Anesthesiology since 1998 and American Academy of Anti-Aging Medicine since 2002. Constance Odom, MD is affiliated with the American Medical Association, American Academy of Anti-Aging Medicine, American Society of Anesthesiology, Georgia Society of Anesthesiology, Hellenic Medical Society of New York, North Carolina Society of Anesthesiology, and Society of Ambulatory Anesthesia.

Credentials

Medical Director At:

• Nu Image Medical
• MetroMedispa P.A.

Staff Anesthesiologist at:

• Betsy Johnson Regional Hospital in Dunn, NC
• Onslow Memorial Hospital in Jacksonville, NC
• Duplin General Hospital in Kenansville, NC

Director of Anesthesia Services at:

• Jacksonville Surgery Center in Jacksonville, NC

Written by our editorial team.

Last Edited 4 weeks ago · 8 min read

Trazodone is widely prescribed for treating insomnia. In low doses, trazodone is known to help increase the availability of serotonin, a neurotransmitter that stabilizes mood and promotes sleep. This makes it an effective solution for those struggling with sleepless nights. While trazodone is generally well-tolerated, some users may experience side effects. 

Understanding these side effects and knowing how to manage them can make your experience with trazodone smoother and more comfortable. In this article, we’ll explore three of the most common side effects of trazodone, particularly when used as a sleep aid and provide practical tips on how to handle them.

1. Drowsiness - Trazodone side effect

One of the most common side effects of trazodone is drowsiness. This effect occurs because trazodone has sedative properties, which is why it is often prescribed to help with sleep disorders. While this can be beneficial for those struggling with insomnia, it can be a challenge for individuals taking trazodone for depression who need to remain alert during the day.

How to handle it

• Take trazodone at night: If possible, take trazodone before bedtime to take advantage of its sedative effects during sleep.

• Adjust your schedule: Plan your activities around your medication schedule, ensuring that tasks requiring high alertness are done before taking trazodone.

• Consult your doctor: If drowsiness is too severe, consult your healthcare provider. They may adjust your dose or recommend taking the medication at a different time.

2. Dizziness - Trazodone side effect

Dizziness is another common side effect of trazodone, particularly when standing up quickly or after changing positions. This occurs because trazodone can cause a drop in blood pressure, leading to feelings of lightheadedness or dizziness.

According to a detailed overview on WebMD, dizziness is a frequent side effect, particularly in the initial stages of treatment or when the dosage is increased.

How to handle it

• Stand up slowly: Avoid sudden movements, especially when rising from a seated or lying position. Stand up slowly to give your body time to adjust.

• Stay hydrated: Dehydration can exacerbate dizziness, so ensure you’re drinking enough water throughout the day.

• Monitor your blood pressure: If dizziness persists, consider checking your blood pressure regularly and discuss any concerns with your healthcare provider.

3. Dry mouth - Trazodone side effect

Dry mouth is a frequent complaint among trazodone users. This side effect occurs because trazodone can reduce saliva production, leading to a dry, uncomfortable mouth. GoodRx explains how certain medications, including trazodone, can lead to dry mouth by affecting the salivary glands.

A discussion on Reddit also highlights how users often seek advice on managing this uncomfortable side effect, showcasing the commonality of dry mouth with trazodone use.

How to handle it

• Stay hydrated: Drink plenty of water throughout the day to keep your mouth moist.

• Use saliva substitutes: Over-the-counter saliva substitutes can help alleviate the discomfort of dry mouth.

• Chew sugar-free gum: Chewing gum or sucking on sugar-free candy can stimulate saliva production and provide relief.

In conclusion, while trazodone is an effective medication for many people, it can come with side effects like drowsiness, dizziness, and dry mouth. These side effects, although common, can often be managed with simple strategies. By understanding how to handle these side effects, you can make your trazodone experience more comfortable and continue benefiting from its therapeutic effects. If you encounter persistent or severe side effects, always consult with your healthcare provider for further advice.

Ready to manage your trazodone side effects effectively?
Learn more about how to use trazodone safely with guidance from Nu Image Medical.

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your physician about the risks and benefits of any treatment. Nu Image Medical may not offer the medications or services mentioned in this article.