Created as a medication to treat addiction, Low Dose Naltrexone triggers a neurochemical reaction on two areas of the brain, the hunger center and the reward system, to reduce hunger and cravings. It decreases the pleasure/reward feelings associated with food, modifies appetite, energy levels, and satiety thresholds after meals.
Low Dose Naltrexone promotes weight loss by modulating appetite. Appetite is partly controlled by POMC cells, which send a “stop eating” signal to the brain by secreting MSH hormone. Low Dose Naltrexone provides continued MSH release, resulting in appetite reduction. It also blocks the anticipatory reward caused by food-related endorphin release and annuls the cravings that lead to non-hunger eating.
Low Dose Naltrexone eliminates cravings by restoring the natural balance of dopamine, which improves the chances of successfully losing weight. It also aids in sleep and has been used as an anti-inflammatory to treat many conditions such as fibromyalgia and Crohn’s disease. By reducing inflammation, Low Dose Naltrexone helps prevent weight gain and the poor health outcomes associated with obesity.