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Created as a medication to treat addiction, Low Dose Naltrexone may also trigger a neurochemical reaction on two areas of the brain, the hunger center and the reward system, to reduce hunger and cravings. It is believed it decreases the pleasure/reward feelings associated with food, modifies appetite, energy levels, and satiety thresholds after meals.
Low Dose Naltrexone may help with weight loss by modulating appetite1. Appetite is partly controlled by POMC cells, which send a “stop eating” signal to the brain by secreting MSH hormone. Low Dose Naltrexone helps provide continued MSH release, which can result in appetite reduction. There has also been evidence that it blocks the anticipatory reward caused by food-related endorphin release and annuls the cravings that lead to non-hunger eating.
Low Dose Naltrexone may eliminate cravings by restoring the natural balance of dopamine, which improves the chances of successfully losing weight. It is also thought to aid in sleep and has been used as an anti-inflammatory to treat many conditions such as fibromyalgia and Crohn’s disease. By reducing inflammation, Low Dose Naltrexone may help to prevent weight gain and the poor health outcomes associated with obesity.