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What effects to expect from stopping Enclomiphene

What effects to expect from stopping Enclomiphene
Dr. Constance Odom, MD Picture of Dr. Constance Odom, MD

Medically reviewed by

Written by our editorial team.

Last Edited 8 min read

Enclomiphene, a medication often used to stimulate testosterone production, has become a popular alternative to traditional testosterone replacement therapy (TRT). If you're considering or currently using Enclomiphene, understanding what happens when you stop taking it is crucial. This article explores the potential effects and considerations of discontinuing Enclomiphene.

Understanding Enclomiphene

Before diving into the effects of stopping Enclomiphene, it's important to grasp how the medication works. Enclomiphene is one of the two isomers of Clomiphene citrate, commonly used in fertility treatments. Unlike Clomiphene, Enclomiphene selectively stimulates the hypothalamus to increase the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn boost testosterone production in men.

What happens when you stop taking Enclomiphene?

When you stop taking Enclomiphene, your body will require time to adjust. You may experience fluctuations in hormone levels and the return of pre-treatment symptoms as your system readapts.

Some individuals might notice changes in energy levels, mood, and overall well-being. It's important to monitor these changes and consult with your healthcare provider to manage any potential side effects or concerns during this transition period.

Fluctuations in hormone levels

One noticeable change after stopping Enclomiphene is the potential drop in hormone levels. Since Enclomiphene stimulates natural testosterone production, discontinuing it might reduce hormone levels, possibly causing fatigue, mood swings, and decreased libido.

Return of Pre-Treatment Symptoms

If you were using Enclomiphene to manage symptoms like low testosterone or infertility, stopping the medication might result in the return of these symptoms. Monitoring any changes and consulting with your healthcare provider is important if significant alterations occur.

Managing the Transition

Gradual Tapering

Abruptly stopping Enclomiphene can exacerbate symptoms. Gradually tapering off the medication under the guidance of a healthcare provider can help mitigate the immediate impacts of discontinuation.

Regular Monitoring

Regular blood tests to monitor hormone levels can provide valuable insights into how your body is adjusting. This helps in making informed decisions about any additional treatments or interventions that may be needed.

Lifestyle Adjustments

Maintaining a healthy lifestyle can support the transition. This includes a balanced diet, regular exercise, adequate sleep, and stress management techniques. Such practices can aid in stabilizing hormone levels and improving overall well-being.

According to discussions on Reddit, individuals who stopped taking Enclomiphene reported that it took about one month for their levels to return to "normal."

Stopping Enclomiphene citrate requires careful consideration and planning. While the body can eventually adjust, the transition period can present various challenges. Regular consultation with healthcare providers, along with lifestyle adjustments, can help manage the effects of discontinuation. Understanding what to expect can make the process smoother and ensure better health outcomes in the long run.

If you have any concerns about stopping Enclomiphene or need personalized advice, don't hesitate to reach out to your healthcare provider. Your health journey is unique, and professional guidance is invaluable in making informed decisions.


This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your physician about the risks and benefits of any treatment. Nu Image Medical may not offer the medications or services mentioned in this article.