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Everything You Need to Know About Hypothalamic Proopiomelanocortin Cells

Everything You Need to Know About Hypothalamic Proopiomelanocortin Cells

When you deal with obesity, it’s important to understand the science behind it. In some instances, there are rare genetic disorders that lead to obesity. Only then can you truly get the help and support that you need.

What are hypothalamic proopiomelanocortin cells?

Proopiomelanocortin (POMC) is a protein precursor that is comprised of biologically active peptides. The POMC cells will release the peptides so that they work within various tissues, helping with a diverse list of biological functions.

When there are POMC-expressing neurons inside of the brain, they help to control pain – and hunger is a form of pain in many instances.

The hypothalamus is responsible for controlling bodily functions, including releasing hormones out of the pituitary gland. 

When you combine Proopiomelanocortin with the functions of the hypothalamus, you get hypothalamic Proopiomelanocortin – which is necessary to maintain normal glucose levels

You need to make sure that the hypothalamus is achieving glucose homeostasis. POMC neurons will inhibit food intake, increase glucose tolerance, and stimulate energy expenditure.

Hypothalamic Proopiomelanocortin cells are necessary inside of the body. When there is a deficiency, you don’t get the glucose homeostasis that your body depends on – though this is often a problem once a person is already obese. Additionally, it can be problematic if you have diabetes.

In some instances, there is a Proopiomelanocortin (POMC) deficiency – and POMC deficiency obesity involves various messages from being sent by the brain. Not everyone is diagnosed properly with this deficiency, leading to a lifetime of obesity. By learning more about the cells and what can be done, you get the medical intervention needed to be healthier. 

POMC Deficiency Obesity: Do you have it?

It’s important to learn about the health of your hypothalamic proopiomelanocortin cells and determine if you have POMC deficiency obesity. Such a diagnosis is very rare, with features including early-onset severe obesity by the age of one, excessive eating with an insatiable hunger, and various endocrine abnormalities. 

If you have POMC deficiency obesity, you likely were diagnosed by the time you are a toddler because of being at or above the 95th percentile in your weight for BMI. Additionally, the insatiable hunger may have led to constant crying – and severe obesity can easily follow you throughout your adult life. 

There may be a few other things you deal with as a result of this diagnosis. You may have low thyroid levels, have experienced delayed puberty during adolescence, have liver disease, and even like skin pigmentation. Many with a POMC deficiency obesity also deal with adrenal insufficiencies from the low levels of the adrenocorticotropic hormone (ACTH). It can also result in dangerously low blood sugar levels and seizures that could be life-threatening if you don’t get the necessary medical intervention.

Lose Weight and Support Your Glucose Levels

Whether you are diabetic or simply on the border, you need to monitor your glucose levels at all times. If there is a spike up or down, it can lead to a number of health problems. 

Many doctors recommend knowing your blood sugar level on a daily basis, particularly if you are a Type I diabetic. A fasting blood sugar level should be less than 100 mg/dL. Two hours after eating, they should be less than 140 mg/dL. 

Now, losing weight is certainly going to help you lower your blood sugar along with also lowering your blood pressure and improving your cholesterol levels. If you are on insulin and other medications, losing weight can help to get you off of these, as long as your doctor approves it.

Your glucose levels may be sporadic when you are trying to lose weight because of not balancing your diet. You also need to be aware of how the hypothalamic POMC cells may be working against you by not sending the necessary signals. Once you have the weight on, the signals may be disrupted to the point that you’re not getting the help that you need. Combine that with a low-calorie diet and it’s no wonder that you’re not getting sufficient support in your effort to lose weight.

How can Naltrexone help?

Naltrexone was originally used to treat addiction within patients. It can work with the neurochemistry of your brain to promote weight loss.

While hypothalamic POMC cells may be diminished when you are obese, preventing your body from being told that your full, naltrexone works to correct that. It allows you to focus on your satiety threshold when you combine it with a low-calorie diet. 

There’s a bit of science involved in how naltrexone works. Food intake happens because your body craves it – or more importantly, your brain is telling your body that you are craving food. You get the anticipatory reward, which is regulated through an endogenous opioid. As you consume food, it releases endorphins, providing you with pleasure.

Naltrexone works to block the rewarding aspects of food so that you decrease the consumption. The hypothalamic POMC cells tell you to stop eating. Since that signal may not be making its way to you, naltrexone gets the job done for you. You don’t get the endorphin release telling you to be happy every time you eat. It allows you to reduce your appetite and focus on the limited calories of your diet.

You can order naltrexone online. The low-dose tablets can be just what’s needed to create the neurochemical reaction within your brain, providing you with not only the way to reduce hunger but also control cravings.

Explore the WAYT-less Diet

You already know about the benefit of naltrexone. What if you could have even more help to guide you on your weight loss goals?

In order to benefit even more, there’s no need to limit yourself solely to ordering naltrexone online. At Nu Image Medical, we make it easy for you to get started on a program that provides you with a winning combination of medications. We pair low dose naltrexone with orlistat and acarbose to offer you the WAYT-less diet program. 

Each of these medications have benefits of their own. Orlistat works to suppress your appetite while also regulating your blood sugar. Acarbose is a benefit because it works just like naltrexone to suppress your appetite and control cravings. However, it also helps you improve your digestion, lower insulin resistance, and block the absorption of carbohydrates and sugars.

With the combination of all three treatments, you get more help so that you don’t get the post-meal glucose spikes. Plus, you don’t have to worry about the POCP that may be telling you that you’re full. As you lose weight, you may even regain more of the hypothalamic POCP cells, helping you to maintain your weight loss year after year.

When you order WAYT-less online with us, you not only get a one-month supply of the medications but also an online doctor visit to ensure that this is going to be the best weight loss option for you. You will get recipes, a cooking guide, and a full diet guide to walk you through the steps to be successful. A licensed and certified nutritionist is available to support you every step of the way. Additionally, access to a program-specific nationwide food delivery makes it easy if you don’t feel like prepping food and cooking every day.

If you’ve tried HCG and other diets only to find that you still aren’t being told that you are full, WAYT-less provides you with the solutions that you need – and you are even able to exercise throughout the program. 

There has never been an easier way to lose weight, particularly when you feel as though nothing else has worked. Contact us at Nu Image Medical today or go ahead and order Naltrexone online by getting started with the WAYT-less diet. 

Nu Image Medical® offers a new and futuristic approach to achieving optimal health and wellness. The company has been a weight loss, anti-aging and wellness provider since 2004 and offers medically supervised programs for medical weight losspeptideserectile dysfunctionscream cream, and hair loss (NuDew) 

About the author

Dr. Richard Smith, MD

4 min read