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The Latest Studies on the Benefits of Hormone Replacement Therapy

The Latest Studies on the Benefits of Hormone Replacement Therapy

Hormones have an enormous influence over our bodies when it comes to aging, weight management, and muscle growth. For many, the benefits of hormone replacement therapy are promising. 

So what are the benefits of hormone replacement therapy and how exactly does this treatment work? Read on to learn more about hormone replacement therapy, what it is, and what it can do for you.

What is Hormone Replacement Therapy?

Hormone replacement therapy is the administration of certain treatments that augment or influence the body's natural hormones. Our body's endocrine system is a network of glands that secrete important chemicals called hormones. These hormones regulate nearly every process in the body, including:

  • Metabolism (which encompasses all chemical and physical processes in the body)

  • Growth and tissue renewal

  • Sexual development and function

Any imbalances in hormonal distribution can cause notable issues. For this reason, more people are turning to hormone replacement therapy in order to take control of their health.

For years, hormone replacement therapy has been associated mainly with women going through menopause. These women were given synthetic hormones to compensate for dropping levels of estrogen. Today, there are more options for replacement therapy that address imbalances in other hormones.

Hormonal Imbalance and Quality of Life

Hormone imbalance is more than just an issue of health. It can affect many aspects and lead to a serious decline in the quality of life. This is especially true for hormones secreted by the hypothalamus and pituitary glands. These glands secrete hormones that regulate:

  • Mood

  • Sleep patterns

  • Sex drive

  • Hunger

  • Body temperature

  • Thirst

  • Growth

The pituitary gland is considered the control center of all the endocrine glands, as this particular gland controls the others. It also makes hormones that are responsible for triggering growth and tissue repair.

The pituitary gland is used by the hypothalamus to send and release hormones that initiate the release of other chemicals that control sex hormones, thyroid hormones, and growth hormone.

Benefits of Hormone Replacement Therapy

When the hormones of the hypothalamus and pituitary gland are not released in appropriate amounts, the effects are not subtle. Such imbalances can occur or worsen because of advancing age, lifestyle choices, poor diet, and stress.

Growth hormone promotes growth in children and adolescents. However, its role is different and equally important in adults. The consequences of low growth hormone release are especially concerning.

What Does Growth Hormone Do?

In adults, growth hormone is essential for maintaining proper body metabolism and structure. This includes regular tissue repair, maintenance, and renewal. It also assists in keeping normal blood glucose levels.

A deficiency in growth hormone in adults causes an overall reduction in well-being. Additionally, it can cause:

  • An increase in body fat

  • An increased cardiovascular disease risk

  • Weakened muscles and bones

  • Dull or sagging skin

  • A weakened or diseased heart

  • Poor sleep quality

  • Poor memory and cognition

  • A compromised immune system

  • Lethargy and a lack of energy

These symptoms can negatively effect a person's life on nearly every level. In addition to serious health risks, a change in appearance can be distressing. Fat gain and muscle loss is a big concern.

What options are there for hormone replacement? There are a few promising therapies for the treatment of growth hormone deficiency.


Sermorelin acetate isn't actual growth hormone. It is an injectable biologically active analog (similarly structured chemical) to the body's own natural growth hormone releasing factor. Growth hormone releasing factor (GHRH) is the chemical that stimulates growth hormone production and release.

Sermorelin is a peptide (string of amino acids) that binds to special receptors to stimulate the pituitary gland to produce and secrete natural growth hormone. This boosts levels in the body, alleviating problems caused by deficiency.

Benefits of Sermorelin

Sermorelin helps increase growth hormone release, consequently improving deficiency symptoms. There have been several long-term benefits reported from the use of sermorelin in treating growth hormone deficiency. These include:

  • Increased endurance and energy

  • Bone density improvement

  • Memory improvement

  • Improved sexual interest and function

  • Emotional stability

  • More elastic skin

  • Improved cardiovascular health and lower blood pressure

  • Improved cholesterol ratios

  • Less body fat

  • Increased lean muscle mass

  • Increased muscle strength

  • Improved immune function

A boost in growth hormone has a significant impact on the health and well-being of those who use sermorelin.


Like sermorelin, ipamorelin is a peptide that mimics the process of natural release of growth hormone. It is an analog of the natural hormone ghrelin.

Ipamorelin initiates growth hormone release from the pituitary gland. It also increases the number of cells that are responsible for this growth hormone release. These cells are called somatrophs. Ipamorelin increases these cells by suppressing the growth hormone-inhibiting chemical somatostatin.

Ipamorelin is one of the safest ways to restore growth hormone levels. It is used to as a therapy for those who are:

  • Experiencing a decline in growth hormone due to aging

  • Suffering from diseases negatively affected by low growth hormone

  • In need of growth hormone support for athletic performance

  • Experiencing growth hormone deficiency for other reasons

Unlike some hormone replacement therapies, ipamorelin does not affect cortisol, prolactin, aldosterone, or acetylcholine release. Because of this, side effects are minimized and the therapy can be administered more frequently.

Benefits of Ipamorelin

Since its function is to increase growth hormone release like sermorelin, the results of their use are similar. Those taking ipamorelin could experience:

  • A decrease in fat and increase in muscle mass and strength

  • Increased energy and endurance

  • Better sleep and reduced insomnia occurrence

  • Improved cognitive function and memory

  • Better skin elasticity

  • Improved bone density and calcium retention

  • Faster healing of connective tissue after injury

  • Better immune system function

Any side effects of ipamorelin are minor and usually disappear in time when used regularly. Like sermorelin, ipamorelin is administered by injection.

Hormone Replacement Therapy for Better Health

There are numerous benefits of hormone replacement therapy. Better hormonal balance leads to a better quality of life. 

Do you feel like you could use a boost and don't know where to start? If you're interested in how growth hormone therapy can benefit you, please contact us today for more information.

About the author

Dr. Constance Odom, MD

8 min read