Don’t Miss a Single Update or New Release! Sign up Today

How Does Sermorelin Peptide Therapy for HGH Replacement Work?

How Does Sermorelin Peptide Therapy for HGH Replacement Work?

Human growth hormone (HGH) deficiency is not uncommon. This condition is present in about 1 out of every 7,000 births.

Although the pituitary gland is small, it €™s immensely important to health and quality of life. Thankfully, human growth hormone deficiency is very treatable.

With hormone replacement therapy, individuals suffering from human growth hormone deficiency can start to feel better. The hard part is deciding what hormone replacement to use. That €™s where Sermorelin peptide comes in.

To find out more about how this treatment can help you, continue reading below.

What Is the Human Growth Hormone?

As a hormone,  HGH is a molecule that helps signal organs to regulate your body €™s processes. Hormones can serve a wide variety of functions. But, the human growth hormone targets the growth, reproduction, and regeneration of human cells.

Some of the obvious effects of the human growth hormone include:

  • Increased height

  • Bone-strengthening  

  • Increased muscle

  • Organ growth

  • Immune system strengthening

  • Other important processes

Although these effects are obvious, there are still many functions of  HGH that scientists have yet to understand.

Not only does its presence affect physical development, but emotional regulation as well. It can affect memory, learning, energy levels, and mental well-being.

Signs of Growth Hormone Deficiency

Thousands of individuals around the world suffer from human growth hormone deficiency. The evolution of cells is essential to the development and aging process in humans. An inadequate supply of the human growth hormone has a negative effect on health and quality of life.

The exact cause of any particular case of growth hormone deficiency is often unclear. It may be due to genetics, specifically a problem with GH1, GHRHR, or BTK. Other causes may include radiation, trauma, tumors, or infections.  

In most cases, the cause of the deficiency is due to pituitary gland issues. Sometimes these present at birth, and sometimes they develop later. To determine if this is the case, blood tests can be performed to measure hormone levels.  

The symptoms of growth hormone deficiency are different in children than in adults.  At birth, signs like micropenis, hypoglycemia, and jaundice may suggest growth hormone deficiency. Later on, other symptoms can present like decreased growth and delayed puberty.  

In adults, growth hormone deficiency involves:

  • Baldness

  • Osteoporosis

  • Less energy

  • Impaired focus

  • Loss of memory

  • Higher LDL cholesterol

  • More body fat

It  can also cause depression and anxiety.    

Growth Hormone Replacement Therapy

Growth hormone replacement therapy is the only treatments for a deficiency. It consists of a prescription medication that must be prescribed by a doctor. Through recombinant DNA technology, scientists can manufacture synthetic growth hormones to help replace what's missing.

The only effective administration of this drug is by intravenous injection into muscle or tissue. The injection can be quite uncomfortable, even painful, for some. Considering these treatments can occur several times a day in many circumstances, the treatment itself can become quite a burden.  

Another issue with this treatment method is the cost. In the United States, a monthly supply can cost anywhere between $500 and $7,500 per month. Unfortunately, it's the only option.

Some individuals are known to use synthetic growth hormones for other purposes, like athletic performance enhancement and to increase agricultural production.  

Benefits of Growth Hormone Replacement Therapy

The effects of growth hormone deficiency are not desirable, but they are treatable. With synthetic forms of the human growth hormone, patients with this condition can see positive results.

For children, this therapy will assist with their growth and development. This improvement can be seen quickly - even within a few months of beginning the therapy. It can also help reduce body fat, improve strength, and improve motor function.

For adults, the desired outcomes are:

  • More muscle

  • More bone density

  • More hair

  • Stronger nails

  • Better immune function

  • Better circulatory function

  • Better blood lipid levels

  • Less body fat

It's quite obvious why people undergo the uncomfortable and pricey therapy.

What Is Sermorelin Peptide?

Sermorelin is a peptide analog of the growth hormone releasing hormone (GHRH). GHRH is a releasing hormone, meaning that it helps stimulate or inhibits the production of the growth hormone.  

GHRH is created in the hypothalamus area of the brain, where it then travels to the pituitary gland. Once it reaches its destination, it tells the pituitary gland how much growth hormone to release.  

Sermorelin was created from a more precise sampling of the same amino acids that GHRH contains. It was composed to target the GHRH receptors to influence human growth hormone production.  

The History of Sermorelin

This compound goes all the way back to 1977, when  Roger Guillemin and Andrew Schally won a Nobel Prize in Medicine for their research in the field. They discovered the exact composition of GHRH, helping doctors everywhere address issues regarding the human growth hormone and the pituitary gland.  

From the 44 amino acids that they identified, W.B. Wehrenberg and N. Ling isolated the 29 amino acids needed to stimulate the pituitary gland. This is the composition of the drug Sermorelin.    

How Sermorelin Works

Within the pituitary gland lies a receptor, known as GHRHr. This receptor is what receives the signals, or messages, from GHRH. Sermorelin, its analog, helps increase those messages.

As a releasing hormone, the introduction of Sermorelin can help tell the pituitary gland to produce more human growth hormone, eliminating the deficiency.  

Due to Sermorelin's short half-life of 10 to 20 minutes, children need to receive several injections of it per day. Adults usually need less of the drug to compensate for their deficiency.  

For the drug to work properly, the patient needs a healthy pituitary gland and healthy GHRH receptors. A specialist will be able to analyze your pituitary function to determine if it will be effective for you.

Hormone Replacement Therapy and More

Hormone replacement therapy is an effective treatment for various hormone deficiencies. For human growth hormone deficiencies in particular, Sermorelin peptide is a great solution.  

Nu Image Medical helps patients with weight loss, hormone replacement, sexual enhancement, and general wellness both digitally and in person. We provide quality medical care without boundaries. 

To find out more about how hormone replacement therapy can help you or a loved one, don't hesitate to contact us.

About the author

Dr. Constance Odom, MD

5 min read