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Harness the Power of These Top Anti-Aging Peptides in Your Skin Care Regime

Harness the Power of These Top Anti-Aging Peptides in Your Skin Care Regime

Growing gracefully old happens best when you look as good as you feel. But as you age things change.

Your skin encompasses your entire body, making it your body's largest organ. Its multilayered anatomy, cell types, and connective tissues work together to protect you from the elements, toxins, and disease.

Some of the contents of your skin that keep it healthy include:

  • the outer epidermis, which contains keratinocytes, made from a tough protein

  • the middle dermis layer, which contains collagen and elastin for stretch and resilience

  • the subcutis, which cushions your face with a fat layer, and gives it a healthy plumpness

  • melanin, a colorful pigment

  • apocrine glands that secrete oils

Your body changes and functions slow down over time, and these protective components break down. Many of these changes create less than favorable results that anti-aging peptides can help prevent and reverse.

Typical Age-Related Skin Changes

As you age, you may experience the following skin changes:

  • the epidermis or outer layer continues to thin

  • melanocytes decrease, which causes paler, more translucent skin

  • pigment changes like age or liver spots

  • the decrease in elastin and collagen creates wrinkles

  • structural changes to the connective tissue create a weathered look

  • aging skin heals four times slower, allowing for pressure ulcers and infections

  • blood vessels start to break easier, causing bruising and marring

Age-related changes also lead to increased skin disorders in people as they grow older. It is important to take good care of your skin early on. You want to prevent or postpone these skin changes.

What Are Anti-Aging Peptides?

Amino acids are the building blocks of protein which, as we said earlier, plays an essential roll in healthy skin structure. Peptides are two or more amino acids linked together in a chain. The size and amino acid sequence of peptides determine their function.

Which Are the Best Peptides for Skin Care?

Certain peptides often go into skin care products due to their anti-aging properties. Read on to learn the top anti-aging peptides to use in your skin care regimen to keep your skin healthy and younger looking.

Palmitoyl Tetrapeptide-7

This peptide consists of the following amino acids in order:

  • glycine

  • glutamine

  • proline

  • arginine

This amino acid chain pairs with palmitic acid, which allows the peptide to penetrate to the deeper layers of the skin, by increasing its oil solubility. By reducing the production of the chemical messenger interleukin, this peptide prevents inflammation.

This is important because inflammation breaks down the collagen and elastin in the skin, creating wrinkles, skin sagging, and uneven skin tone over time. Research also suggests that this peptide can trigger skin regeneration, which decreases as we age.

Palmitoyl Oligopeptide

This polypeptide consists of the amino acids:

  • glycine

  • histidine

  • lysine

These also work with the palmitic acid to penetrate the skin and work at a deeper level. Palmitoyl Oligopeptide stimulates production hyaluronic acid in the subcutis.

This stimulates collagen production. Collagen provides integrity, firmness, and elasticity, to reduce the wrinkles and thinning of the skin. Furthermore, this peptide helps to protect the skin against sun damage, by partially blocking ultraviolet rays.

Heptapeptide Acetyl-DEETGEF-OH

By signaling Nrf2-dependent antioxidant enzymes, this peptide keeps the skin healthy indirectly through cell DNA protection. It works by eliminating free radicals that damage our skin and promote aging.

Due to the reduction of these free radicals, products containing this peptide help prevent skin damage. Studies also show that applying to sun-exposed areas Heptapeptide Acetyl-DEETGEF-OH reduces sun damage by 20%.


Pentapeptides are amino acids that contain a chain of five or more amino acids. They are natural peptides for the skin. These peptides for skin work to heal and to stimulate collagen and elastin production for a more youthful look.

They also stimulate the release of hyaluronic acid. You will often find hydrating creams with hyaluronic acid because it increases your skin's ability to hold on to moisture. This increases firmness, creating more pliable skin a plumper appearance.

These are some of the best peptides for skin if you desire softer, smoother, and glowing skin. Myristoyl pentapeptide-10 and pentapeptide-1 both stimulate keratin production, which we said earlier forms the most superficial layer of our skin. This makes these pentapeptides excellent options for regenerating your skin.

Hexapeptides contain a chain of six amino acids. Many manufacturers compare this type of peptide skincare to Botox, due to the anti-wrinkle effect. The benefits of this treatment over botox derive from the fact that it is non-evasive, unlike Botox, which requires an injection.

One example of a skin care hexapeptide used for skin care is acetyl hexapeptide-3. People use creams with this peptide to reduce wrinkles from deeper levels of the skin.

This natural peptide for skin care works by interrupting the signal that causes muscles to contract. This interruption causes an effect that mimics flaccid paralysis. reducing muscle tension relaxes facial wrinkles.

Acetyl sh-Heptapeptide-1

This new heptapeptide contains a string of seven amino acids. It works to stimulate Nrf2 activity, enhancing protection against reactive chemicals. This peptide also works at a cellular level to reduce oxidative stress that causes the skin to age prematurely.

Researchers also found that this heptapeptide also reduces skin damage from UV rays by reducing the number of sunburn cells in the skin. Meaning, it increases both the skins capacity to protect itself and fights aging due to natural aging and environmental factors.

Copper Peptides

Another skin care option includes mixing protein with small particles of copper. This helps to enhance healing properties in the skin as well as regeneration.

Copper peptides for skin care also increase elasticity and firmness in the skin because they boost collagen and elastin production. These natural peptides slow down the aging process and reduce the appearance of aging.

Note that you should not attempt to make your own copper peptides at home. Copper metal is toxic and should not be rubbed onto the skin in other forms.

Snake Venom Peptide

Aging bites. So bite back with creams devised of snake venom peptides!


Vipers produce a powerful venom that contains high concentrations of phospholipase A2. This protein creates a neurotoxin that causes paralysis. Though devastating if large amounts flush into the bloodstream, this venom creates an effect similar to Botox, which works due to a bacterial neurotoxin from Clostridium botulinum.

This neurotoxic effect works to reduce wrinkles when locally applied because it creates a flaccid paralysis. These natural peptides for skin relax the muscle, eliminating the pull on the skin that forms the crease.

Other Ways to Battle Aging

Using skin care products with peptides will help keep your skin looking younger and healthier. But you can optimize your appearance by taking care of yourself by adding the following to your skin care regimen.


Hydrating well will help keep your skin from looking older. Proper hydration keeps your skin from appearing tight, dry, and flakey. This will also help reduce skin aging because dehydration makes your skin prone to wrinkling because it will have less resilience.

To keep your skin properly hydrated:

  • drink 8 or more glasses of water each day

  • apply a hydrating peptide moisturizer right after showering

  • with your peptide moisturizer, use a product that contains hyaluronic acid

Remember, this is not something that happens after a one time use. You need to make this a common practice to keep your skin young and healthy.

Sun Protection

Though people decide the healthy glow of a suntan, double think about your future skin. Sun exposure can cause premature skin aging, skin damage, and sunspots, which leave blotches of dark pigment in sun-exposed areas.

To protect your skin from the sun:

  • apply sunscreen when you go outdoors

  • regularly use a peptide cream containing Heptapeptide Acetyl-DEETGEF-OH

  • wear a wide-brimmed hat when spending time outside

  • still cover even when it is cloudy, as UV rays penetrate clouds

Enjoy the sun, but keep your skin protected when you do.

Proper Skin Nutrition

Applying the peptide creams to your skin keeps you looking young, but continue the aging battle from the inside as well. Eat foods that promote younger looking skin, like foods from the hCG diet.

Fruits and vegetables provide us with antioxidants, like the peptide cream, Heptapeptide Acetyl-DEETGEF-OH. Antioxidants remove cell-damaging unattached oxygens from our bodies for a gene written younger appearance!

Many studies suggest that melons especially offer anti-aging skin effects. Eating plenty of fruits and vegetables will also help keep your skin hydrated.

Foods high in protein, like beans, quinoa, seafood, and eggs, work on your insides for your skin the way that your anti-aging peptides work from the outside. Peptides form from chains of amino acids, and amino acids are the building blocks of proteins.

Omega-6 fatty acids build our cell membranes, making them another fantastic nutrient for skin care. To get enough of this nutrient, incorporate nuts, flaxseed oil, grape seed oil, and acai into your diet.

Add Peptides to Your Skin Care Regimen

When deciding on a skin care regimen, make sure you add in anti-aging peptides to slow down and even reverse the effects of aging. Shop with us for a healthier, more youthful version of you!

About the author

Dr. Constance Odom, MD

8 min read