HGH, produced by the pituitary gland, spurs growth in children and adolescents. It also helps to regulate body composition, body fluids, muscle and bone growth, sugar and fat metabolism, and possibly heart function. It is thus important in human development. It is a type of mitogen which is specific only to certain kinds of cells. Growth hormone is a 191-amino acid, single-chain polypeptide that is synthesized, stored, and secreted by somatotropic cells within the lateral wings of the anterior pituitary gland.
The study of human growth hormone has been going on for a little over 100 years, and in 1985, bio-synthetic human growth hormone replaced pituitary-derived human growth hormone for therapeutic use in the U.S. and elsewhere, and it was approved by the FDA for specific use in adults and children.
Human Growth hormone can be injected into larger doses to promote weight loss and increased muscle size, while small doses can be used for general recovery, anti-aging treatments, or general health. Currently, there is a growing list of positive benefits of HGH treatments in children, adults, and people of all ages.
The most obvious and well known benefit of Human Growth Hormone is increased muscle strength. HGH has been known to improve the physical ability of individuals through stimulating collagen synthesis in the skeletal muscle and tendons, increase strength and improving exercise performance as a result. In the International Journal of Endocrinology, a study with 14 healthy men at the ages of 50 to 70 were randomized into two groups. Seven subjects were administered HGH therapy with seven placebo subjects, and they were re-evaluated after six months. After six months, there was a significant increase in the leg press responsiveness muscles in the growth hormone group.
Overall, the study concluded an increase in muscle strength in the lower body of the group after human growth hormone was administered in health men. In HGH-deficient adults, participants who were administered long term treatment experienced normalization of muscle strength, increased exercise capacity, and improved thermoregulation and body fat composition.
Another benefit often found with HGH therapy is enhanced weight loss. Obese individuals have limited response to growth hormone, and after successful reduction of weight, responsiveness can become partial or complete. Growth hormone accelerates the breakdown of lipids and frees fatty acids, and impaired secretion of HGH leads to loss of this effect.
Dietary restrictions and growth hormone treatment effects on anabolic and lipolytic actions as well as the changes in growth hormone secretions and insulin were investigated in a study published in Hormone Research. Twenty-four obese participants were on a hypocaloric diet and treated with recombinant human growth hormone or a placebo in a double-blinded, 12-week randomized study. As a result, growth hormone treatment caused a 1.6-fold increase in weight loss, with the greatest loss being visceral fat compared to the placebo.
Yet another benefit of HGH is an increase in bone density. The hormone is essential for regulating bone growth, and stimulates the production of IGF-1, which is produced in the liver. With age, bone density may decrees, but with the re-introduction of HGH IGF-1 and growth hormone stimulates the bone forming and bone reabsorbing cells, increasing bone mass.